Reduced ADC was seen in GBM- PNET (mean 581 Ã- 10(-6) mm(2)/s, range 338-817) compared to previously published mean of 1,030 Ã- 10(-6) mm(2)/s in the enhancing components of conventional GBMs. Results were compared to previously published ADC values in pathology-proven conventional GBM cases from our institution. DWI (diffusion-weighted imaging) sequences were analyzed with multiple regions of interests placed within the tumor, and ADC (apparent diffusion coefficient) values were measured. MR images of these patients were reviewed retrospectively. Nine patients with surgical specimens yielding GBM- PNET were identified from the UCSF Pathology files. The purpose of this study is to quantitatively evaluate the diffusion characteristics in GBM- PNET and compare them with conventional GBMs.
The imaging appearance of GBM- PNET is not well-described and given areas of marked cellularity in the PNET components one might expect significantly reduced diffusion on MRI. Recent studies describe PNET-like clinical behavior in these patients-with significantly increased propensity for CSF dissemination and a benefit of " PNET-like" chemotherapy. Glioblastoma (GBM) with primitive neuroectodermal tumor ( PNET)-like (GBM- PNET) components is a rare variant of GBM. Apparent diffusion coefficient in glioblastoma with PNET-like components, a GBM variant.Īli, Saad Joseph, Nancy M Perry, Arie Barajas, Ramon F Cha, Soonmee
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